Pancreatic cancer stem cells

Stem cell treatment for pancreatic cancer consists in designing a cellular strategy to control the growth of cancer cells in the pancreas. Identification of pancreatic cancer stem cells and further elucidation of the signaling pathways that regulate their growth and survival may provide novel therapeutic approaches to treat pancreatic cancer, which is notoriously resistant to standard chemotherapy and radiation. In pancreatic cancer, ALDH cells appear to have a gene expression profile consistent with EMT and increased invasive and migratory potential as compared with bulk tumor cells and CDCDcells. One to two in every hundred cases of a pancreatic cancer are neuroendocrine tumors, which arise from the hormone-producing cells in the pancreas.

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